Epistemix Inc.

Pittsburgh, PA, United States


Epistemix empowers leaders to make better decisions by simulating the health impacts of the choices they face. Our team has spent decades building epidemiological models to combat smallpox, measles, HIV, SARS, MERS, the opioid crisis, and other epidemics. Now, we’re working with health care systems, schools, Fortune 500s, nonprofits, researchers, and federal, state, and local governments to respond to COVID-19. Our platform simulates the specific, local health impacts of particular policy interventions like adjusting social distancing rules, establishing return-to-office protocols, and planning vaccine distribution—giving decisions-makers the insight they need to take action.



Epistemix provides decision-support services to leadership teams responding to COVID-19 across the public and private sector. We build computational models that simulate the specific health impacts of competing strategies so they can be compared, evaluated, and communicated. We are helping state and local governments plan vaccine deployment, schools define and manage reopening programs, large event producers analyze operational risk, and major employers establish return-to-office protocols. Our simulations account for every individual person, household, neighborhood, school, and workplace in the United States, as well as local demographic characteristics including age, sex, and race. We consider differences in population density, contact patterns, household structure, cross-immunity from prior infections, vaccine uptake, and social distancing policies. We incorporate the latest local public health data, calibrate the simulation to local conditions, and then use realistic social dynamics based on the actual strategies being implemented to estimate the impact of interventions—yielding actionable insights. The best decision is a fully informed decision.

Services Provided:

Application Development, Data Model & Database Design, GIS Strategy and Planning, Implementation, System Integration, Training Services